More restrictive lung disease Treatment options for RLD Restrictive lung disease is a group of thoracic deformities that result in inefficient coupling between the respiratory mu scles and the thoracic cage. What is restrictive lung disease? Restrictive lung disease refers to a group of thoracic deformities that result in inefficient coupling between the respiratory muscles and the thoracic cage. Reference Kelly, JL et al. Randomized trial of ‘intelligent’ autotitrating ventilation versus standard pressure support non-invasive ventilation: Impact on adherence and physiological outcomes. Respirology. 2014 May;19(4):596-603.